Interaction #1 nef - AP2S1
(1) TRG_LysEnd_APsAcLL_1 motif (160ENTSLL165) in Nef protein (nef)
(2) Clathrin adaptor complex small chain (1-142) in AP-2 complex subunit sigma (AP2S1)
Effector binding Induction (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the Nef protein (nef) TRG_LysEnd_APsAcLL_1 motif - AP-2 complex subunit sigma (AP2S1) Clathrin adaptor complex small chain interaction
(1) Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.
Other switches involving participants