Switch #: SWTI000237

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Protein Nef (nef) via an endocytosis motif.

Participants:
(1) Protein Nef (nef)
(2) AP-2 complex subunit sigma (AP2S1)

(1) A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.
Bresnahan et al. Curr. Biol. (1998)

(2) Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.
Craig et al. Proc. Natl. Acad. Sci. U.S.A. (1998)

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)