Switch #: SWTI000246

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of the all-trans-retinoic acid ligand to the nuclear Retinoic acid receptor alpha (RARA) makes the binding site for the CORNRBOX motif of Nuclear receptor corepressor 1 (NCOR1) inaccessible.

Participants:
(1) Nuclear receptor corepressor 1 (NCOR1)
(2) Retinoic acid receptor alpha (RARA)

(1) A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
le Maire et al. Nat. Struct. Mol. Biol. (2010)

Other switches involving participants
Retinoic acid receptor alpha (RARA) - 2 more (view)
Nuclear receptor corepressor 1 (NCOR1) - 1 more (view)

Other switches involving interfaces
LIG_CORNRBOX - 3 more (view)
Ligand-binding domain of nuclear hormone receptor - 21 more (view)