Description: Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Copper-transporting ATPase 1 (ATP7A) via an endocytosis motif.
Participants: (1) Copper-transporting ATPase 1 (ATP7A) (2) AP-2 complex subunit sigma (AP2S1)
(1) Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.Greenough et al. Am. J. Physiol., Cell Physiol. (2004) (2) The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal.Petris et al. Hum. Mol. Genet. (1999)
Other switches involving participantsAP-2 complex subunit sigma (AP2S1) - 11 more (view)Other switches involving interfacesTRG_LysEnd_APsAcLL_1 - 14 more (view)Clathrin adaptor complex small chain - 15 more (view)
