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Switch #:
SWTI000244
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit sigma (AP2S1) subunit for recruitment of Beta-secretase 1 (BACE1) via an endocytosis motif.

Participants:
(1) Beta-secretase 1 (BACE1)
(2) AP-2 complex subunit sigma (AP2S1)

Interactions
Interaction #1 BACE1 - AP2S1

Interfaces
(1) TRG_LysEnd_APsAcLL_1 motif (495DDISLL500) in Beta-secretase 1 (BACE1)
(2) Clathrin adaptor complex small chain (1-142) in AP-2 complex subunit sigma (AP2S1)

Interaction Regulation
Effector binding Induction (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the Beta-secretase 1 (BACE1) TRG_LysEnd_APsAcLL_1 motif - AP-2 complex subunit sigma (AP2S1) Clathrin adaptor complex small chain interaction

Additional Information
Structural information: 1UJK
Context
Switch localisation
ELM curated: Endocytic vesicle, cytosol
References

(1) Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.
Shiba et al. Traffic (2004)

See also

Other switches involving participants
AP-2 complex subunit sigma (AP2S1) - 11 more (view)

Other switches involving interfaces
TRG_LysEnd_APsAcLL_1 - 14 more (view)
Clathrin adaptor complex small chain - 15 more (view)


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