Switch #: SWTI000261

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of the glucocorticoid ligand to the nuclear Glucocorticoid receptor (NR3C1) makes the binding site for the NRBOX motif of Nuclear receptor coactivator 2 (NCOA2) accessible.

Participants:
(1) Nuclear receptor coactivator 2 (NCOA2)
(2) Glucocorticoid receptor (NR3C1)

(1) The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
Voegel et al. EMBO J. (1998)

(2) Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
Bledsoe et al. Cell (2002)

Other switches involving participants
Nuclear receptor coactivator 2 (NCOA2) - 2 more (view)
Glucocorticoid receptor (NR3C1) - 2 more (view)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)