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Binding of the glucocorticoid ligand to the nuclear Glucocorticoid receptor (NR3C1) makes the binding site for the NRBOX motif of Nuclear receptor coactivator 2 (NCOA2) accessible.

(1) Nuclear receptor coactivator 2 (NCOA2)
(2) Glucocorticoid receptor (NR3C1)

Interaction #1 NCOA2 - NR3C1

(1) LIG_NRBOX motif (744LLRYLLD750) in Nuclear receptor coactivator 2 (NCOA2)
(2) Ligand-binding domain of nuclear hormone receptor (542-753) in Glucocorticoid receptor (NR3C1)

Interaction Regulation
Effector binding Induction (glucocorticoid) of the Nuclear receptor coactivator 2 (NCOA2) LIG_NRBOX motif - Glucocorticoid receptor (NR3C1) Ligand-binding domain of nuclear hormone receptor interaction

Additional Information
Structural information: 1M2Z

(1) The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
Voegel et al. EMBO J. (1998)

(2) Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.
Bledsoe et al. Cell (2002)

See also

Other switches involving participants
Nuclear receptor coactivator 2 (NCOA2) - 2 more (view)
Glucocorticoid receptor (NR3C1) - 2 more (view)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)

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