Switch #: SWTI000263

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of the 3,3',5-triiodo-L-thyronine ligand to the nuclear Thyroid hormone receptor alpha (THRA) makes the binding site for the NRBOX motif of Mediator of RNA polymerase II transcription subunit 1 (MED1) accessible.

Participants:
(1) Mediator of RNA polymerase II transcription subunit 1 (MED1)
(2) Thyroid hormone receptor alpha (THRA)

(1) An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.
Coulthard et al. J. Biol. Chem. (2003)

(2) The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.
Yuan et al. Proc. Natl. Acad. Sci. U.S.A. (1998)

(3) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.
Malik et al. Mol. Cell. Biol. (2004)

Other switches involving participants
Mediator of RNA polymerase II transcription subunit 1 (MED1) - 1 more (view)
Thyroid hormone receptor alpha (THRA) - 1 more (view)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)