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Binding of the 3,3',5-triiodo-L-thyronine ligand to the nuclear Thyroid hormone receptor alpha (THRA) makes the binding site for the NRBOX motif of Mediator of RNA polymerase II transcription subunit 1 (MED1) accessible.

(1) Mediator of RNA polymerase II transcription subunit 1 (MED1)
(2) Thyroid hormone receptor alpha (THRA)

Switch localisation
Curated: nucleus
ELM curated: nucleus

(1) An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.
Coulthard et al. J. Biol. Chem. (2003)

(2) The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.
Yuan et al. Proc. Natl. Acad. Sci. U.S.A. (1998)

(3) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.
Malik et al. Mol. Cell. Biol. (2004)

See also

Other switches involving participants
Mediator of RNA polymerase II transcription subunit 1 (MED1) - 1 more (view)
Thyroid hormone receptor alpha (THRA) - 1 more (view)

Other switches involving interfaces
Ligand-binding domain of nuclear hormone receptor - 21 more (view)
LIG_NRBOX - 17 more (view)

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