Switch #: SWTI000267

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to Wiskott-Aldrich syndrome protein (WAS) allosterically relieves an auto-inhibitory intramolecular interaction in Wiskott-Aldrich syndrome protein (WAS), which becomes active.

Participants:
(1) Wiskott-Aldrich syndrome protein (WAS)

(1) Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.
Rohatgi et al. J. Cell Biol. (2000)

(2) Physical mechanisms of signal integration by WASP family proteins.
Padrick et al. Annu. Rev. Biochem. (2010)

(3) Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.
Prehoda et al. Science (2000)

(4) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Kim et al. Nature (2000)

Other switches involving participants
Wiskott-Aldrich syndrome protein (WAS) - 2 more (view)

Other switches involving interfaces
ELM:LIG_GBD_WASP_1 - 5 more (view)
P21-Rho-binding domain - 5 more (view)