Switch #: SWTI000268

Switch type: Binary

Switch subtype: Allostery

Description:
Binding of Cell division control protein 42 homolog (CDC42) to Neural Wiskott-Aldrich syndrome protein (WASL) allosterically relieves an auto-inhibitory intramolecular interaction in Neural Wiskott-Aldrich syndrome protein (WASL), which becomes active.

Participants:
(1) Neural Wiskott-Aldrich syndrome protein (WASL)

(1) A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
Panchal et al. Nat. Struct. Biol. (2003)

(2) Arp2/3 complex is bound and activated by two WASP proteins.
Padrick et al. Proc. Natl. Acad. Sci. U.S.A. (2011)

(3) Physical mechanisms of signal integration by WASP family proteins.
Padrick et al. Annu. Rev. Biochem. (2010)

Other switches involving participants
Neural Wiskott-Aldrich syndrome protein (WASL) - 2 more (view)

Other switches involving interfaces
ELM:LIG_GBD_WASP_1 - 5 more (view)
P21-Rho-binding domain - 5 more (view)