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Switch #:
SWTI000269
Switch type:
Binary
Switch subtype:
Allostery

Description:
Binding of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to Neural Wiskott-Aldrich syndrome protein (WASL) allosterically relieves an auto-inhibitory intramolecular interaction in Neural Wiskott-Aldrich syndrome protein (WASL), which becomes active.

Participants:
(1) Neural Wiskott-Aldrich syndrome protein (WASL)

Interactions
Interaction #1 WASL - WASL(intramolecular)
intramolecular
Interfaces
(1) ELM:LIG_GBD_WASP_1 motif (467IVGALMEVMQK477) in Neural Wiskott-Aldrich syndrome protein (WASL)
(2) P21-Rho-binding domain (202-261) in Neural Wiskott-Aldrich syndrome protein (WASL)

Interaction Regulation
Effector binding Inhibition (1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate) of the Neural Wiskott-Aldrich syndrome protein (WASL) LIG_GBD_WASP_1 motif - Neural Wiskott-Aldrich syndrome protein (WASL) P21-Rho-binding domain interaction

References

(1) Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.
Rohatgi et al. J. Cell Biol. (2000)

(2) Physical mechanisms of signal integration by WASP family proteins.
Padrick et al. Annu. Rev. Biochem. (2010)

(3) Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.
Prehoda et al. Science (2000)

See also

Other switches involving participants
Neural Wiskott-Aldrich syndrome protein (WASL) - 2 more (view)

Other switches involving interfaces
ELM:LIG_GBD_WASP_1 - 5 more (view)
P21-Rho-binding domain - 5 more (view)




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