Description:
Multisite phosphorylation of S46 and T55 in the PH-like binding motif of Cellular tumor antigen p53 (TP53) gradually enhances its affinity for General transcription factor IIH subunit 1 (GTF2H1), an interaction involved in activation of transcription initiation and elongation by Cellular tumor antigen p53 (TP53). Participants:
(1) Cellular tumor antigen p53 (TP53)
(2) General transcription factor IIH subunit 1 (GTF2H1)
Interaction #1 TP53 - GTF2H1Interfaces (1) ELM:LIG_PH_Tfb1 motif ( 50IEQWFTE56) in Cellular tumor antigen p53 (TP53)(2) TFIIH p62 subunit, N-terminal domain (9-81) in General transcription factor IIH subunit 1 (GTF2H1)Interaction Regulation PTM-dependent Enhancement (Phosphorylation of S46 and T55 on Cellular tumor antigen p53 (TP53)) of the Cellular tumor antigen p53 (TP53) LIG_PH_Tfb1 motif - General transcription factor IIH subunit 1 (GTF2H1) TFIIH p62 subunit, N-terminal domain interaction Inferred Regulatory Enzymes for switchPutative modifying enzymes for residue: S46 : Serine-protein kinase ATM (ATM), ATM, Cyclin-dependent kinase 5 (CDK5), DNA-dependent protein kinase catalytic subunit (PRKDC), Protein kinase C delta type (PRKCD), Mitogen-activated protein kinase 14 (MAPK14), Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2), Homeodomain-interacting protein kinase 2 (HIPK2). T55 : MAPK_group, Mitogen-activated protein kinase 1 (MAPK1), G protein-coupled receptor kinase 5 (GRK5), Transcription initiation factor TFIID subunit 1 (TAF1).
Additional Information
Affinity : S46-T55: 3.175 µM, pS46-T55: 0.518 µM, S46-pT55: 0.457 µM, pS46-pT55: 0.097 µM
Structural information: 2GS0
(1) Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53.
Di Lello et al. Mol. Cell (2006) Other switches involving participants
Cellular tumor antigen p53 (TP53) - 10 more (view)
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