Interaction #1 APP - GRB2
(1) LIG_SH2_GRB2 motif (757YENP760) in Amyloid beta A4 protein (APP)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)
PTM-dependent Enhancement (Phosphorylation of Y757 and T743 on Amyloid beta A4 protein (APP)) of the Amyloid beta A4 protein (APP) LIG_SH2_GRB2 motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: T743 : Glycogen synthase kinase-3 beta (GSK3B), Cyclin-dependent kinase 1 (CDK1). Y757 : Tyrosine-protein kinase Fyn (FYN).
Affinity : T743-Y757: no binding µM, T743-pY757: 0.00257 µM, pT743-pY757:0.000413 µM
(1) The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.
Other switches involving participants