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While phosphorylation of Y757 in the SH2-binding motif of Amyloid beta A4 protein (APP) induces binding to Growth factor receptor-bound protein 2 (GRB2), additional phosphorylation of T743 further increases the strength of the interaction.

(1) Amyloid beta A4 protein (APP)
(2) Growth factor receptor-bound protein 2 (GRB2)

Interaction #1 APP - GRB2

(1) LIG_SH2_GRB2 motif (757YENP760) in Amyloid beta A4 protein (APP)
(2) SH2 domain (60-135) in Growth factor receptor-bound protein 2 (GRB2)

Interaction Regulation
PTM-dependent Enhancement (Phosphorylation of Y757 and T743 on Amyloid beta A4 protein (APP)) of the Amyloid beta A4 protein (APP) LIG_SH2_GRB2 motif - Growth factor receptor-bound protein 2 (GRB2) SH2 domain interaction

Additional Information
Affinity : T743-Y757: no binding µM, T743-pY757: 0.00257 µM, pT743-pY757:0.000413 µM

(1) The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains.
Tamayev et al. Mol Neurodegener (2009)

See also

Other switches involving participants
Amyloid beta A4 protein (APP) - 2 more (view)
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_GRB2 - 6 more (view)

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