Interaction #1 ITGB3 - SHC1
(1) LIG_PTB_Phospho_1 motif (779TFTNITY785) in Integrin beta-3 (ITGB3)
(2) Phosphotyrosine interaction domain (PTB/PID) (162-318) in SHC-transforming protein 1 (SHC1)
PTM-dependent Enhancement (Phosphorylation of Y785 and Y773 on Integrin beta-3 (ITGB3)) of the Integrin beta-3 (ITGB3) LIG_PTB_Phospho_1 motif - SHC-transforming protein 1 (SHC1) Phosphotyrosine interaction domain (PTB/PID) interaction
Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y773 : Proto-oncogene tyrosine-protein kinase Src (SRC). Y785 : Tyrosine-protein kinase SYK (SYK), Proto-oncogene tyrosine-protein kinase Src (SRC).
Structural information: 2L1C
ELM curated: integrin, cytoplasmic membrane-bounded vesicle, cytosol, internal side of plasma membrane, receptor complex
(1) Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling.
Other switches involving participants