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Switch #:
SWTI000276
Switch type:
Cumulative
Switch subtype:
Rheostatic

Description:
Phosphorylation of S2789 and S2793 adjacent to the EBH-binding motif of Adenomatous polyposis coli protein (APC), by , respectively, gradually reduces the affinity of its interaction with Microtubule-associated protein RP/EB family member 1 (MAPRE1).

Participants:
(1) Adenomatous polyposis coli protein (APC)
(2) Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Interactions
Interaction #1 APC - MAPRE1

Interfaces
(1) LIG_SxIP_EBH_1 motif (2801RPSQIPTPVNN2811) in Adenomatous polyposis coli protein (APC)
(2) EB1-like C-terminal motif (209-248) in Microtubule-associated protein RP/EB family member 1 (MAPRE1)

Interaction Regulation
PTM-dependent Inhibition (Phosphorylation of S2789 and S2793 on Adenomatous polyposis coli protein (APC)) of the Adenomatous polyposis coli protein (APC) LIG_SxIP_EBH_1 motif - Microtubule-associated protein RP/EB family member 1 (MAPRE1) EB1-like C-terminal motif interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S2789: Cyclin-dependent kinase 1 (CDK1); S2793: GSK-3 subfamily

Additional Information
Affinity : S2789-S2793: 5.8 µM, pS2789-S2793: 17.9 µM, S2789-pS2793: 32 µM
Context
References

(1) Structural insights into the EB1-APC interaction.
Honnappa et al. EMBO J. (2005)

(2) An EB1-binding motif acts as a microtubule tip localization signal.
Honnappa et al. Cell (2009)

See also

Other switches involving participants
Microtubule-associated protein RP/EB family member 1 (MAPRE1) - 2 more (view)

Other switches involving interfaces
LIG_SxIP_EBH_1 - 2 more (view)
EB1-like C-terminal motif - 2 more (view)




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