Switch #: SWTI000287

Switch type: Specificity

Switch subtype: Altered binding specificity

Description:
Phosphorylation of T-cell surface glycoprotein CD3 epsilon chain (CD3E) by Lck (Tyrosine-protein kinase Lck (LCK)) during T cell activation switches the specificity of CD3E from SH3 domain containing proteins like Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) to SH2 domain containing proteins like Tyrosine-protein kinase ZAP-70 (ZAP70).

Participants:
(1) T-cell surface glycoprotein CD3 epsilon chain (CD3E)
(2) Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)
(3) Tyrosine-protein kinase ZAP-70 (ZAP70)

(1) Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.
Kesti et al. J. Immunol. (2007)

Other switches involving participants
T-cell surface glycoprotein CD3 epsilon chain (CD3E) - 2 more (view)
Tyrosine-protein kinase ZAP-70 (ZAP70) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
SH3 domain - 7 more (view)
LIG_SH3_5 - 1 more (view)
LIG_TYR_ITAM - 8 more (view)