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Switch #:
SWTI000288
Switch type:
Specificity
Switch subtype:
Altered binding specificity

Description:
Phosphorylation of T758 in Integrin beta-2 (ITGB2) switches the specificity of ITGB2 from Filamin-A (FLNA) to 14-3-3 proteins (e.g. 14-3-3 protein zeta/delta (YWHAZ)).

Participants:
(1) Integrin beta-2 (ITGB2)
(2) Filamin-A (FLNA)
(3) 14-3-3 protein zeta/delta (YWHAZ)

Interactions
Interaction #1 ITGB2 - FLNA

Is mutually exclusive with Interaction #2 ITGB2 - YWHAZ

Interfaces
(1) ELM:LIG_Filamin motif (753LFKSATTTVMN763) in Integrin beta-2 (ITGB2)
(2) Filamin/ABP280 repeat (2235-2322) in Filamin-A (FLNA)

Interaction Regulation
PTM-dependent Abrogation (Phosphorylation of T758 on Integrin beta-2 (ITGB2)) of the Integrin beta-2 (ITGB2) LIG_Filamin motif - Filamin-A (FLNA) Filamin/ABP280 repeat interaction


Additional Information
Affinity : T758: 500 µM, pT758: no binding µM
Structural information: 2JF1
Interaction #2 ITGB2 - YWHAZ

Is mutually exclusive with Interaction #1 ITGB2 - FLNA

Interfaces
(3) LIG_14-3-3_3 motif (755KSATTT760) in Integrin beta-2 (ITGB2)
(4) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (YWHAZ)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of T758 on Integrin beta-2 (ITGB2)) of the Integrin beta-2 (ITGB2) LIG_14-3-3_3 motif - 14-3-3 protein zeta/delta (YWHAZ) 14-3-3 protein interaction


Additional Information
Affinity : T758: no binding µM, pT758: 0.261 µM
Structural information: 2V7D
Context
References

(1) Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.
Takala et al. Blood (2008)

See also

Other switches involving participants
14-3-3 protein zeta/delta (YWHAZ) - 11 more (view)
Filamin-A (FLNA) - 2 more (view)

Other switches involving interfaces
LIG_14-3-3_3 - 16 more (view)
14-3-3 protein - 38 more (view)
ELM:LIG_Filamin - 1 more (view)
Filamin/ABP280 repeat - 3 more (view)




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