Switch #: SWTI000298

Switch type: Pre-assembly

Switch subtype: Composite binding site formation

Description:
Binding of EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand.

Participants:
(1) Integrin alpha-V (ITGAV)
(2) Integrin beta-3 (ITGB3)
(3) EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)

This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step

1Interaction #1 ITGAV - ITGB3

Interfaces
(1) FG-GAP repeat in Integrin alpha-V (ITGAV)
(2) Integrin, beta chain _(38-461) in Integrin beta-3 (ITGB3)

2Interaction #2 EDIL3 - Interaction #1 ITGAV - ITGB3

Requires Interaction #1 ITGAV - ITGB3

Interfaces
(3) LIG_RGD motif (₉₆RGD₉₈) in EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)
(4) Interaction #1 ITGAV - ITGB3

(1) Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor.
Hidai et al. Genes Dev. (1998)

Other switches involving participants
Integrin beta-3 (ITGB3) - 15 more (view)
Integrin alpha-V (ITGAV) - 8 more (view)

Other switches involving interfaces
FG-GAP repeat - 13 more (view)
Integrin, beta chain - 13 more (view)
LIG_RGD - 12 more (view)