Switch #: SWTI000307

Switch type: Pre-assembly

Switch subtype: Composite binding site formation

Description:
Binding of Disintegrin trigramin-beta-2 to integrin receptors depends on pre-assembly of Integrin alpha-IIb (ITGA2B)-Integrin beta-3 (ITGB3) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand.

Participants:
(1) Integrin alpha-IIb (ITGA2B)
(2) Integrin beta-3 (ITGB3)
(3) Disintegrin trigramin-beta-2

This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step

1Interaction #1 ITGA2B - ITGB3

Interfaces
(1) FG-GAP repeat in Integrin alpha-IIb (ITGA2B)
(2) Integrin, beta chain _(38-461) in Integrin beta-3 (ITGB3)

2Interaction #2 - Interaction #1 ITGA2B - ITGB3

Requires Interaction #1 ITGA2B - ITGB3

Interfaces
(3) LIG_RGD motif (₅₁RGD₅₃) in Disintegrin trigramin-beta-2
(4) Interaction #1 ITGA2B - ITGB3

(1) Trigramin: primary structure and its inhibition of von Willebrand factor binding to glycoprotein IIb/IIIa complex on human platelets.
Huang et al. Biochemistry (1989)

Other switches involving participants
Integrin beta-3 (ITGB3) - 15 more (view)
Integrin alpha-IIb (ITGA2B) - 2 more (view)

Other switches involving interfaces
FG-GAP repeat - 13 more (view)
Integrin, beta chain - 13 more (view)
LIG_RGD - 12 more (view)