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Switch #:
SWTI000308
Switch type:
Pre-assembly
Switch subtype:
Composite binding site formation

Description:
Binding of Genome polyprotein to integrin receptors depends on pre-assembly of Integrin alpha-V (ITGAV)-Integrin beta-6 (ITGB6) heterodimers, since association of the integrin alpha and beta subunits results in the formation of a composite binding site for the RGD motif in the ligand.

Participants:
(1) Integrin alpha-V (ITGAV)
(2) Integrin beta-6 (ITGB6)
(3) Genome polyprotein

Interactions
This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step
2Interaction #2 - Interaction #1 ITGAV - ITGB6

Requires Interaction #1 ITGAV - ITGB6

Interfaces
(3) LIG_RGD motif (858RGD860) in Genome polyprotein
(4) Interaction #1 ITGAV - ITGB6
Context
References

(1) Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9.
Williams et al. J. Virol. (2004)

See also

Other switches involving participants
Integrin alpha-V (ITGAV) - 8 more (view)
Integrin beta-6 (ITGB6) - 1 more (view)

Other switches involving interfaces
FG-GAP repeat - 13 more (view)
Integrin, beta chain - 13 more (view)
LIG_RGD - 12 more (view)




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