This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step
1Interaction #1 Itgav - Itgb3
(1) FG-GAP repeat in Integrin alpha-V (Itgav)
(2) Integrin, beta chain (37-460) in Integrin beta-3 (Itgb3)
Curated: plasma membrane, extracellular matrix
ELM curated: integrin, extracellular
(1) Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells.