Description: Participants: Interactions This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step 1Interaction #1 Cks1b - Skp2 Interfaces (1) Cyclin-dependent kinase regulatory subunit in Cyclin-dependent kinases regulatory subunit 1 (Cks1b) (2) Leucine rich repeat (205-229) and (230-254) and (255-280) and (334-359) in S-phase kinase-associated protein 2 (Skp2) 1Interaction #2 Cdkn1c - Cdk2 Interfaces (3) MOD_CDK_1 motif (339VEQTPRK345) in Cyclin-dependent kinase inhibitor 1C (Cdkn1c) (4) Protein kinase domain (4-220) and (238-334) in Cyclin-dependent kinase 2 (Cdk2) 2Interaction #3 Cdkn1c - Interaction #1 Cks1b - Skp2 Requires Interaction #1 Cks1b - Skp2 Requires Interaction #2 Cdkn1c - Cdk2 Interfaces (5) DEG_SCF_SKP2-CKS1_1 motif (338AVEQTPRK345) in Cyclin-dependent kinase inhibitor 1C (Cdkn1c) (6) Interaction #1 Cks1b - Skp2 Interaction Regulation PTM-dependent Induction (Phosphorylation of T342 on Cyclin-dependent kinase inhibitor 1C (Cdkn1c)) of the Cyclin-dependent kinase inhibitor 1C (Cdkn1c) DEG_SCF_SKP2-CKS1_1 motif - interaction Regulatory Enzymes for switch Modifying enzymes for residue: T342: Cyclin-dependent kinase 2 (Cdk2) Context Switch localisation Curated: nucleus ELM curated: nucleus, cytosol, cycloplasmic cyclin-dependent protein kinase holoenzyme complex, SCF ubiquitin ligase complex Switch cell cycle phase Curated: mitotic S phase Switch pathways Curated: Cell cycle References (1) Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. See also Other switches involving interfaces |
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