Description: Participants: Interactions ![]() 1Interaction #1 Cks1b - Skp2 Interfaces (1) Cyclin-dependent kinase regulatory subunit in Cyclin-dependent kinases regulatory subunit 1 (Cks1b) (2) Leucine rich repeat (205-229) and (230-254) and (255-280) and (334-359) in S-phase kinase-associated protein 2 (Skp2) 1Interaction #2 Cdkn1c - Cdk2 Interfaces (3) MOD_CDK_1 motif (339VEQTPRK345) in Cyclin-dependent kinase inhibitor 1C (Cdkn1c) (4) Protein kinase domain (4-220) and (238-334) in Cyclin-dependent kinase 2 (Cdk2) 2Interaction #3 Cdkn1c - Interaction #1 Cks1b - Skp2 Requires Interaction #1 Cks1b - Skp2 Requires Interaction #2 Cdkn1c - Cdk2 Interfaces (5) DEG_SCF_SKP2-CKS1_1 motif (338AVEQTPRK345) in Cyclin-dependent kinase inhibitor 1C (Cdkn1c) (6) Interaction #1 Cks1b - Skp2 Interaction Regulation PTM-dependent Induction (Phosphorylation of T342 on Cyclin-dependent kinase inhibitor 1C (Cdkn1c)) of the Cyclin-dependent kinase inhibitor 1C (Cdkn1c) DEG_SCF_SKP2-CKS1_1 motif - interaction Regulatory Enzymes for switch Modifying enzymes for residue: T342: Cyclin-dependent kinase 2 (Cdk2) Context Switch localisation Curated: nucleus ELM curated: nucleus, cytosol, cycloplasmic cyclin-dependent protein kinase holoenzyme complex, SCF ubiquitin ligase complex Switch cell cycle phase Curated: mitotic S phase Switch pathways Curated: Cell cycle References (1) Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation. See also Other switches involving interfaces |
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