Switch #: SWTI000315

Switch type: Specificity

Switch subtype: Motif hiding

Description:
Inhibition of nuclear import of Large T antigen by phosphorylation-dependent (T124) binding of BRCA1-associated protein (BRAP).

Participants:
(1) Large T antigen
(2) BRCA1-associated protein (BRAP)
(3) Importin subunit alpha-1 (KPNA1)

(1) The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal.
Fulcher et al. FASEB J. (2010)

(2) Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.
Li et al. J. Biol. Chem. (1998)

Other switches involving participants
Large T antigen - 2 more (view)
BRCA1-associated protein (BRAP) - 1 more (view)
Importin subunit alpha-1 (KPNA1) - 9 more (view)

Other switches involving interfaces
TRG_NLS_MonoExtN_4 - 10 more (view)
Armadillo/beta-catenin-like repeat - 16 more (view)
coiled_coil;PFAM:Pfam-B_17154 - 1 more (view)