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Switch #:
SWTI000317
Switch type:
Specificity
Switch subtype:
Motif hiding

Description:
Phosphorylation-induced binding of dimeric 14-3-3 protein beta/alpha (YWHAB) to Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) blocks ER retention motifs in Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) and regulates transport of this protein to the membrane.

Participants:
(1) Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
(2) 14-3-3 protein beta/alpha (YWHAB)
(3) Coatomer subunit beta (COPB1)

Interactions
Interaction #1 ADAM22 - YWHAB

Is mutually exclusive with Interaction #2 ADAM22 - COPB1

Interfaces
(1) LIG_14-3-3_3 motif (831RSNSWQ836 and 854RSNSTE859) in Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
(2) 14-3-3 protein (5-238) in 14-3-3 protein beta/alpha (YWHAB)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S834 and S857 on Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)) of the Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) LIG_14-3-3_3 motif - 14-3-3 protein beta/alpha (YWHAB) 14-3-3 protein interaction

Interaction #2 ADAM22 - COPB1

Is mutually exclusive with Interaction #1 ADAM22 - YWHAB

Interfaces
(3) TRG_ER_diArg_1 motif (829RPR831 and 851FRPR854) in Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
(4) Adaptin N terminal region (18-539) in Coatomer subunit beta (COPB1)

Interaction Regulation
Effector binding Abrogation (14-3-3 protein beta/alpha (YWHAB)) of the Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) TRG_ER_diArg_1 motif - Coatomer subunit beta (COPB1) Adaptin N terminal region interaction

Context
Switch localisation
ELM curated: nucleus, cytosol, internal side of plasma membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna, endoplasmic reticulum membrane, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, Golgi-ER transport vesicle membrane
Inferred: cytosol
References

(1) Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members.
Gödde et al. J. Cell. Sci. (2006)

See also

Other switches involving participants
14-3-3 protein beta/alpha (YWHAB) - 8 more (view)
Coatomer subunit beta (COPB1) - 8 more (view)
Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22) - 1 more (view)

Other switches involving interfaces
LIG_14-3-3_3 - 16 more (view)
14-3-3 protein - 38 more (view)
TRG_ER_diArg_1 - 7 more (view)
Adaptin N terminal region - 8 more (view)


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