About Help Definitions Submit Search Analyse Browse Home

Switch #:
Switch type:
Switch subtype:
Motif hiding

Hiding of the NLS of MKL/myocardin-like protein 1 (Mkl1) by binding of G-actin to the RPEL motifs of MKL/myocardin-like protein 1 (Mkl1) prevents translocation of this transcription factor to the nucleus.

(1) MKL/myocardin-like protein 1 (Mkl1)
(2) Actin, alpha skeletal muscle (Acta1)
(3) Importin subunit alpha-3 (Kpna3)

Interaction #1 Mkl1 - Acta1

Is mutually exclusive with Interaction #2 Mkl1 - Kpna3

(1) LIG_Actin_RPEL_3 motif (17LQLKLQQRRTREELVSQGIM36 and 61LKRKIRSRPERAELVRMHIL80 and 105LNEKIAQRPGPMELVEKNIL124) in MKL/myocardin-like protein 1 (Mkl1)
(2) Actin (4-377) in Actin, alpha skeletal muscle (Acta1)
Additional Information
Structural information: 2YJF
Interaction #2 Mkl1 - Kpna3

Is mutually exclusive with Interaction #1 Mkl1 - Acta1

(3) TRG_NLS_MonoExtN_4 motif (62KRKIRS67 and 95KLKRARL101) in MKL/myocardin-like protein 1 (Mkl1)
(4) Armadillo/beta-catenin-like repeat (104-438) in Importin subunit alpha-3 (Kpna3)

Interaction Regulation
Effector binding Abrogation (Actin, alpha skeletal muscle (Acta1)) of the MKL/myocardin-like protein 1 (Mkl1) TRG_NLS_MonoExtN_4 motif - Importin subunit alpha-3 (Kpna3) Armadillo/beta-catenin-like repeat interaction

Additional Information
Structural information: 2YJF

(1) An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.
Pawłowski et al. EMBO J. (2010)

(2) Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.
Mouilleron et al. Sci Signal (2011)

See also

Other switches involving participants
Actin, alpha skeletal muscle (Acta1) - 2 more (view)

Other switches involving interfaces
TRG_NLS_MonoExtN_4 - 10 more (view)
Armadillo/beta-catenin-like repeat - 16 more (view)
LIG_Actin_RPEL_3 - 2 more (view)
Actin - 3 more (view)

Loading visualisation

Please send any suggestions/comments to: switches@elm.eu.org