Switch #: SWTI000319

Switch type: Specificity

Switch subtype: Motif hiding

Description:
Phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB) promotes cell surface expression of G-protein coupled receptor 15 (GPR15) by releasing the receptor from the ER retrieval/retention pathway that is mediated by the interaction of its ER retention motif with Coatomer subunit beta (COPB1).

Participants:
(1) G-protein coupled receptor 15 (GPR15)
(2) 14-3-3 protein beta/alpha (YWHAB)
(3) Coatomer subunit beta (COPB1)

(1) Phosphorylation-dependent C-terminal binding of 14-3-3 proteins promotes cell surface expression of HIV co-receptor GPR15.
Okamoto et al. J. Biol. Chem. (2011)

Other switches involving participants
14-3-3 protein beta/alpha (YWHAB) - 8 more (view)
Coatomer subunit beta (COPB1) - 8 more (view)

Other switches involving interfaces
14-3-3 protein - 38 more (view)
TRG_ER_diArg_1 - 7 more (view)
Adaptin N terminal region - 8 more (view)
ELM:LIG_14-3-3_4 - 1 more (view)