Switch #: SWTI000320

Switch type: Specificity

Switch subtype: Motif hiding

Description:
The basic ER retention motif of HLA class II histocompatibility antigen gamma chain (CD74) is blocked from binding to Coatomer subunit beta (COPB1) by phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB), regulating its release from the ER and trafficking to the plasma membrane.

Participants:
(1) HLA class II histocompatibility antigen gamma chain (CD74)
(2) 14-3-3 protein beta/alpha (YWHAB)
(3) Coatomer subunit beta (COPB1)

(1) Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.
O'Kelly et al. Cell (2002)

Other switches involving participants
14-3-3 protein beta/alpha (YWHAB) - 8 more (view)
Coatomer subunit beta (COPB1) - 8 more (view)
HLA class II histocompatibility antigen gamma chain (CD74) - 1 more (view)

Other switches involving interfaces
LIG_14-3-3_3 - 16 more (view)
14-3-3 protein - 38 more (view)
TRG_ER_diArg_1 - 7 more (view)
Adaptin N terminal region - 8 more (view)