Description: The basic ER retention motif of HLA class II histocompatibility antigen gamma chain (CD74) is blocked from binding to Coatomer subunit beta (COPB1) by phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB), regulating its release from the ER and trafficking to the plasma membrane.
Participants: (1) HLA class II histocompatibility antigen gamma chain (CD74) (2) 14-3-3 protein beta/alpha (YWHAB) (3) Coatomer subunit beta (COPB1)
(1) Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.O'Kelly et al. Cell (2002)
Other switches involving participants14-3-3 protein beta/alpha (YWHAB) - 8 more (view)Coatomer subunit beta (COPB1) - 8 more (view)HLA class II histocompatibility antigen gamma chain (CD74) - 1 more (view)Other switches involving interfacesLIG_14-3-3_3 - 16 more (view)14-3-3 protein - 38 more (view)TRG_ER_diArg_1 - 7 more (view)Adaptin N terminal region - 8 more (view)
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