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Switch #:
SWTI000321
Switch type:
Specificity
Switch subtype:
Motif hiding

Description:
Interaction of the GABA receptor R2 subunit (Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)) with the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)) via coiled-coil forming domains masks the ER retention motif in the R1 subunit (Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)), thereby promoting surface expression of fully assembled GABA receptors.

Participants:
(1) Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1)
(2) Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)
(3) Coatomer subunit beta (COPB1)

Interactions
Context
References

(1) Hide and run. Arginine-based endoplasmic-reticulum-sorting motifs in the assembly of heteromultimeric membrane proteins.
Michelsen et al. EMBO Rep. (2005)

See also

Other switches involving participants
Coatomer subunit beta (COPB1) - 8 more (view)

Other switches involving interfaces
TRG_ER_diArg_1 - 7 more (view)
Adaptin N terminal region - 8 more (view)




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