Switch #: SWTI000343

Switch type: Avidity-sensing

Description:
Hierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).

Participants:
(1) DNA repair protein XRCC1 (XRCC1)
(2) Bifunctional polynucleotide phosphatase/kinase (PNKP)

(1) Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK.
Ali et al. Nucleic Acids Res. (2009)

(2) The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.
Loizou et al. Cell (2004)

(3) A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment.
Luo et al. Mol. Cell. Biol. (2004)

Other switches involving participants
DNA repair protein XRCC1 (XRCC1) - 2 more (view)
Bifunctional polynucleotide phosphatase/kinase (PNKP) - 2 more (view)

Other switches involving interfaces
LIG_FHA_2 - 9 more (view)
IPR:IPR008984 - 3 more (view)