Switch #: SWTI000342

Switch type: Specificity

Switch subtype: Competition

Description:
The PDZ domains of Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) and SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) compete for the PDZ-binding motif of Cystic fibrosis transmembrane conductance regulator (CFTR). SLC9A3R1 positively regulates CFTR activity by recruiting a PKA-containing complex, while SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) negatively affects CFTR activity by recruiting PDE4D.

Participants:
(1) Cystic fibrosis transmembrane conductance regulator (CFTR)
(2) Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1)
(3) SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)

(1) Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors.
Lee et al. J. Biol. Chem. (2007)

Other switches involving participants
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (SLC9A3R1) - 5 more (view)

Other switches involving interfaces
PDZ domain (Also known as DHR or GLGF) - 45 more (view)
LIG_PDZ_Class_1 - 41 more (view)