Description: Participants: Interactions Interaction #1 DAG1 - DMD Is mutually exclusive with Interaction #2 DAG1 - GRB2 Interfaces (1) LIG_WW_1 motif (889PPPY892) in Dystroglycan (DAG1) (2) WW domain (3057-3086) in Dystrophin (DMD) Interaction Regulation Effector binding Inhibition (Growth factor receptor-bound protein 2 (GRB2)) of the Dystroglycan (DAG1) LIG_WW_1 motif - Dystrophin (DMD) WW domain interaction Additional Information Structural information: 1EG4 Interaction #2 DAG1 - GRB2 Is mutually exclusive with Interaction #1 DAG1 - DMD Interfaces (3) LIG_SH3_3 motif (888SPPPYVP894) in Dystroglycan (DAG1) (4) SH3 domain (4-50) in Growth factor receptor-bound protein 2 (GRB2) Interaction Regulation Effector binding Inhibition (Dystrophin (DMD)) of the Dystroglycan (DAG1) LIG_SH3_3 motif - Growth factor receptor-bound protein 2 (GRB2) SH3 domain interaction Context Switch localisation ELM curated: cytosol, integral membrane protein, integral plasma membrane protein, focal adhesion, plasma membrane References (1) Characterization of the beta-dystroglycan-growth factor receptor 2 (Grb2) interaction. See also Other switches involving participants |
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