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Switch #:
SWTI000340
Switch type:
Specificity
Switch subtype:
Competition

Description:
Sorting nexin-9 (SNX9) and fructose-1,6-bisphosphate (D-fructose 1,6-bisphosphate) bind mutually exclusive and with similar affinities to Fructose-bisphosphate aldolase A (ALDOA).

Participants:
(1) Sorting nexin-9 (SNX9)
(2) Fructose-bisphosphate aldolase A (ALDOA)
(3) D-fructose 1,6-bisphosphate

Interactions
Interaction #1 SNX9 - ALDOA

Is mutually exclusive with Interaction #2 - ALDOA

Interfaces
(1) ELM:LIG_Glycolytic_Aldolase motif (165WDEDW169) in Sorting nexin-9 (SNX9)
(2) Fructose-bisphosphate aldolase class-I (15-364) in Fructose-bisphosphate aldolase A (ALDOA)

Interaction Regulation
Effector binding Inhibition (D-fructose 1,6-bisphosphate) of the Sorting nexin-9 (SNX9) LIG_Glycolytic_Aldolase motif - Fructose-bisphosphate aldolase A (ALDOA) Fructose-bisphosphate aldolase class-I interaction

Additional Information
Structural information: 3LGE
Interaction #2 - ALDOA

Is mutually exclusive with Interaction #1 SNX9 - ALDOA

Interfaces
(3) D-fructose 1,6-bisphosphate
(4) Fructose-bisphosphate aldolase class-I (15-364) in Fructose-bisphosphate aldolase A (ALDOA)

Interaction Regulation
Effector binding Inhibition (Sorting nexin-9 (SNX9)) of the D-fructose 1,6-bisphosphate motif - Fructose-bisphosphate aldolase A (ALDOA) Fructose-bisphosphate aldolase class-I interaction

Additional Information
Structural information: 1ZAI
References

(1) Mechanism of aldolase control of sorting nexin 9 function in endocytosis.
Rangarajan et al. J. Biol. Chem. (2010)

(2) Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.
Lundmark et al. J. Biol. Chem. (2004)

See also

Other switches involving participants
Sorting nexin-9 (SNX9) - 1 more (view)
Fructose-bisphosphate aldolase A (ALDOA) - 1 more (view)

Other switches involving interfaces
ELM:LIG_Glycolytic_Aldolase - 1 more (view)
Fructose-bisphosphate aldolase class-I - 1 more (view)




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