Switches.ELM

Switch #:

SWTI000340

Switch type:
Specificity

Switch subtype:
Competition

Description:
Sorting nexin-9 (SNX9) and fructose-1,6-bisphosphate (D-fructose 1,6-bisphosphate) bind mutually exclusive and with similar affinities to Fructose-bisphosphate aldolase A (ALDOA).

Participants:
(1) Sorting nexin-9 (SNX9)
(2) Fructose-bisphosphate aldolase A (ALDOA)
(3) D-fructose 1,6-bisphosphate

Interactions

Interaction #1 SNX9 - ALDOA

Is mutually exclusive with Interaction #2 - ALDOA

Interfaces
(1) ELM:LIG_Glycolytic_Aldolase motif (₁₆₅WDEDW₁₆₉) in Sorting nexin-9 (SNX9)
(2) Fructose-bisphosphate aldolase class-I_(15-364) in Fructose-bisphosphate aldolase A (ALDOA)

Interaction Regulation
Effector binding Inhibition (D-fructose 1,6-bisphosphate) of the Sorting nexin-9 (SNX9) LIG_Glycolytic_Aldolase motif - Fructose-bisphosphate aldolase A (ALDOA) Fructose-bisphosphate aldolase class-I interaction

Additional Information
Structural information: 3LGE

Interaction #2 - ALDOA

Is mutually exclusive with Interaction #1 SNX9 - ALDOA

Interfaces
(3) D-fructose 1,6-bisphosphate
(4) Fructose-bisphosphate aldolase class-I_(15-364) in Fructose-bisphosphate aldolase A (ALDOA)

Interaction Regulation
Effector binding Inhibition (Sorting nexin-9 (SNX9)) of the D-fructose 1,6-bisphosphate motif - Fructose-bisphosphate aldolase A (ALDOA) Fructose-bisphosphate aldolase class-I interaction

Additional Information
Structural information: 1ZAI

References

(1) Mechanism of aldolase control of sorting nexin 9 function in endocytosis.
Rangarajan et al. J. Biol. Chem. (2010)

(2) Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.
Lundmark et al. J. Biol. Chem. (2004)