Switch #: SWTI000339

Switch type: Specificity

Switch subtype: Competition

Description:
The docking sites for PP1 (e.g. Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)) and Cdk-Cyclins (e.g. Cyclin-A2 (CCNA2)) on Retinoblastoma-associated protein (RB1) overlap, which makes their binding to RB1 mutually exclusive. Hypophosphorylated RB1 blocks E2F-dependent transcription, while hyperphosphorylation inactivates RB1 as a repressor, thereby promoting cell cycle progression.

Participants:
(1) Retinoblastoma-associated protein (RB1)
(2) Cyclin-A2 (CCNA2)
(3) Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

(1) An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.
Hirschi et al. Nat. Struct. Mol. Biol. (2010)

Other switches involving participants
Cyclin-A2 (CCNA2) - 1 more (view)
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) - 1 more (view)

Other switches involving interfaces
DOC_CYCLIN_1 - 3 more (view)
Cyclin, N-terminal domain - 3 more (view)
Calcineurin-like phosphoesterase - 5 more (view)
DOC_PP1 - 4 more (view)