Description: Phosphorylation of Y182 and Y193 in the ITAM motif of B-cell antigen receptor complex-associated protein alpha chain (Cd79a) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (Syk). Maximal Syk activation requires both Syk SH2 domains and phosphorylation of both ITAM tyrosine residues.
Participants: (1) B-cell antigen receptor complex-associated protein alpha chain (Cd79a) (2) Tyrosine-protein kinase SYK (Syk)
(1) Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation.Rowley et al. J. Biol. Chem. (1995)
Other switches involving interfacesSH2 domain - 140 more (view)LIG_TYR_ITAM - 8 more (view)
