Switch #: SWTI000346

Switch type: Avidity-sensing

Description:
Phosphorylation of Y188 and Y199 in the ITAM motif of T-cell surface glycoprotein CD3 epsilon chain (CD3E) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).

Participants:
(1) T-cell surface glycoprotein CD3 epsilon chain (CD3E)
(2) Tyrosine-protein kinase SYK (SYK)

(1) Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.
Fütterer et al. J. Mol. Biol. (1998)

Other switches involving participants
T-cell surface glycoprotein CD3 epsilon chain (CD3E) - 2 more (view)
Tyrosine-protein kinase SYK (SYK) - 4 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITAM - 8 more (view)