Switch #: SWTI000347

Switch type: Avidity-sensing

Description:
Phosphorylation of Y111 and Y123 in the ITAM motif of T-cell surface glycoprotein CD3 zeta chain (CD247) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase ZAP-70 (ZAP70).

Participants:
(1) T-cell surface glycoprotein CD3 zeta chain (CD247)
(2) Tyrosine-protein kinase ZAP-70 (ZAP70)

(1) The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor zeta chain tyrosine-based activation motif.
Osman et al. Eur. J. Immunol. (1995)

(2) Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.
Bu et al. Proc. Natl. Acad. Sci. U.S.A. (1995)

Other switches involving participants
Tyrosine-protein kinase ZAP-70 (ZAP70) - 5 more (view)
T-cell surface glycoprotein CD3 zeta chain (CD247) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITAM - 8 more (view)