Switch #: SWTI000352

Switch type: Avidity-sensing

Description:
Phosphorylation of Y65 and Y76 in the ITAM motif of High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) induces high-avidity binding to the tandem SH2 domains of Tyrosine-protein kinase SYK (SYK).

Participants:
(1) High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)
(2) Tyrosine-protein kinase SYK (SYK)

(1) Molecular mechanism of the Syk activation switch.
Tsang et al. J. Biol. Chem. (2008)

Other switches involving participants
Tyrosine-protein kinase SYK (SYK) - 4 more (view)
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_TYR_ITAM - 8 more (view)