Description: Participants: Interactions ![]() 1Interaction #1 YWHAZ - YWHAZ Interfaces (1) 14-3-3 protein in 14-3-3 protein zeta/delta (YWHAZ) (2) 14-3-3 protein (3-236) in 14-3-3 protein zeta/delta (YWHAZ) Additional Information Structural information: 2WH0 2Interaction #2 PRKCE - Interaction #1 YWHAZ - YWHAZ Requires Interaction #1 YWHAZ - YWHAZ Interfaces (3) LIG_14-3-3_3 motif (343RSKSAP348) in Protein kinase C epsilon type (PRKCE) (4) Interaction #1 YWHAZ - YWHAZ Interaction Regulation PTM-dependent Induction (Phosphorylation of S346 on Protein kinase C epsilon type (PRKCE)) of the Protein kinase C epsilon type (PRKCE) LIG_14-3-3_3 motif - 14-3-3 protein interaction Additional Information Affinity : pS346-S368: 9.8 µM, S346-pS368: >100 µM, pS346-pS368: 0.059 µM Structural information: 2WH0 2Interaction #3 PRKCE - Interaction #1 YWHAZ - YWHAZ Requires Interaction #1 YWHAZ - YWHAZ Interfaces (5) LIG_14-3-3_3 motif (365KALSFD370) in Protein kinase C epsilon type (PRKCE) (6) Interaction #1 YWHAZ - YWHAZ Interaction Regulation PTM-dependent Induction (Phosphorylation of S368 on Protein kinase C epsilon type (PRKCE)) of the Protein kinase C epsilon type (PRKCE) LIG_14-3-3_3 motif - 14-3-3 protein interaction Inferred Regulatory Enzymes for switch Putative modifying enzymes for residue: S368 : Protein kinase C alpha type (PRKCA), Protein kinase C epsilon type (PRKCE). Additional Information Affinity : pS346-S368: 9.8 µM, S346-pS368: >100 µM, pS346-pS368: 0.059 µM Structural information: 2WH0 Context References (1) Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon. See also Other switches involving participants |
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