Description: Participants: Interactions ![]() 1Interaction #1 YWHAB - YWHAB Interfaces (1) 14-3-3 protein in 14-3-3 protein beta/alpha (YWHAB) (2) 14-3-3 protein (5-238) in 14-3-3 protein beta/alpha (YWHAB) 2Interaction #2 FOXO3 - Interaction #1 YWHAB - YWHAB Requires Interaction #1 YWHAB - YWHAB Interfaces (3) LIG_14-3-3_3 motif (250RAVSMD255) in Forkhead box protein O3 (FOXO3) (4) Interaction #1 YWHAB - YWHAB Interaction Regulation PTM-dependent Induction (Phosphorylation of S253 on Forkhead box protein O3 (FOXO3)) of the Forkhead box protein O3 (FOXO3) LIG_14-3-3_3 motif - 14-3-3 protein interaction Regulatory Enzymes for switch Modifying enzymes for residue: S253: RAC-alpha serine/threonine-protein kinase (AKT1) 2Interaction #3 FOXO3 - Interaction #1 YWHAB - YWHAB Requires Interaction #1 YWHAB - YWHAB Interfaces (5) LIG_14-3-3_3 motif (29RSCTWP34) in Forkhead box protein O3 (FOXO3) (6) Interaction #1 YWHAB - YWHAB Interaction Regulation PTM-dependent Induction (Phosphorylation of T32 on Forkhead box protein O3 (FOXO3)) of the Forkhead box protein O3 (FOXO3) LIG_14-3-3_3 motif - 14-3-3 protein interaction Regulatory Enzymes for switch Modifying enzymes for residue: T32: RAC-alpha serine/threonine-protein kinase (AKT1) Inferred Regulatory Enzymes for switch Putative modifying enzymes for residue: T32 : PKB_group, SGK_group, RAC-alpha serine/threonine-protein kinase (AKT1), RAC-alpha serine/threonine-protein kinase (Akt1), Serine/threonine-protein kinase pim-1 (PIM1). Context Switch localisation ELM curated: nucleus, cytosol, internal side of plasma membrane Switch pathways Curated: PI3K-Akt signaling pathway References (1) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. See also Other switches involving participants |
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