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Switch #:
SWTI000356
Switch type:
Avidity-sensing

Description:
Phosphorylation of two 14-3-3-binding motifs in Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) induces high-avidity binding to dimeric 14-3-3 protein beta/alpha (YWHAB).

Participants:
(1) 14-3-3 protein beta/alpha (YWHAB)
(2) Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)

Interactions
This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step
2Interaction #2 PTPN3 - Interaction #1 YWHAB - YWHAB

Requires Interaction #1 YWHAB - YWHAB

Interfaces
(3) LIG_14-3-3_3 motif (356RSLSVE361) in Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)
(4) Interaction #1 YWHAB - YWHAB

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S359 on Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)) of the Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) LIG_14-3-3_3 motif - 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S359: MAP/microtubule affinity-regulating kinase 3 (MARK3)

2Interaction #3 PTPN3 - Interaction #1 YWHAB - YWHAB

Requires Interaction #1 YWHAB - YWHAB

Interfaces
(5) LIG_14-3-3_3 motif (832RVDSEP837) in Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)
(6) Interaction #1 YWHAB - YWHAB

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S835 on Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)) of the Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) LIG_14-3-3_3 motif - 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S359: MAP/microtubule affinity-regulating kinase 3 (MARK3)

Context
References

(1) Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein.
Zhang et al. J. Biol. Chem. (1997)

See also

Other switches involving participants
14-3-3 protein beta/alpha (YWHAB) - 8 more (view)

Other switches involving interfaces
14-3-3 protein - 38 more (view)
LIG_14-3-3_3 - 16 more (view)




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