Switch #: SWTI000356

Switch type: Avidity-sensing

Description:
Phosphorylation of two 14-3-3-binding motifs in Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) induces high-avidity binding to dimeric 14-3-3 protein beta/alpha (YWHAB).

Participants:
(1) 14-3-3 protein beta/alpha (YWHAB)
(2) Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)

This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step

1Interaction #1 YWHAB - YWHAB

Interfaces
(1) 14-3-3 protein in 14-3-3 protein beta/alpha (YWHAB)
(2) 14-3-3 protein _(5-238) in 14-3-3 protein beta/alpha (YWHAB)

2Interaction #2 PTPN3 - Interaction #1 YWHAB - YWHAB

Requires Interaction #1 YWHAB - YWHAB

Interfaces
(3) LIG_14-3-3_3 motif (₃₅₆RSLSVE₃₆₁) in Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)
(4) Interaction #1 YWHAB - YWHAB

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₃₅₉ on Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)) of the Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) LIG_14-3-3_3 motif - 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₃₅₉: MAP/microtubule affinity-regulating kinase 3 (MARK3)

2Interaction #3 PTPN3 - Interaction #1 YWHAB - YWHAB

Requires Interaction #1 YWHAB - YWHAB

Interfaces
(5) LIG_14-3-3_3 motif (₈₃₂RVDSEP₈₃₇) in Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)
(6) Interaction #1 YWHAB - YWHAB

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S₈₃₅ on Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)) of the Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) LIG_14-3-3_3 motif - 14-3-3 protein interaction

Regulatory Enzymes for switch
Modifying enzymes for residue: S₃₅₉: MAP/microtubule affinity-regulating kinase 3 (MARK3)

(1) Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein.
Zhang et al. J. Biol. Chem. (1997)

Other switches involving participants
14-3-3 protein beta/alpha (YWHAB) - 8 more (view)

Other switches involving interfaces
14-3-3 protein - 38 more (view)
LIG_14-3-3_3 - 16 more (view)