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Switch #:
SWTI000359
Switch type:
Avidity-sensing

Description:
Phosphorylation of two 14-3-3-binding motifs in Insulin receptor substrate 1 (IRS1) induces high-avidity binding to dimeric 14-3-3 protein epsilon (YWHAE).

Participants:
(1) 14-3-3 protein epsilon (YWHAE)
(2) Insulin receptor substrate 1 (IRS1)

Interactions
This is a sequential switch. The interactions in this switch take place in a defined order. The order is defined by numbers to the left of each interaction. More than one interaction can occur in each step, these interactions occur independently but are necessary for future step
2Interaction #2 IRS1 - Interaction #1 YWHAE - YWHAE

Requires Interaction #1 YWHAE - YWHAE

Interfaces
(3) LIG_14-3-3_3 motif (371HSRSIP376) in Insulin receptor substrate 1 (IRS1)
(4) Interaction #1 YWHAE - YWHAE

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S374 on Insulin receptor substrate 1 (IRS1)) of the Insulin receptor substrate 1 (IRS1) LIG_14-3-3_3 motif - 14-3-3 protein interaction

2Interaction #3 IRS1 - Interaction #1 YWHAE - YWHAE

Requires Interaction #1 YWHAE - YWHAE

Interfaces
(5) LIG_14-3-3_3 motif (638KSVSAP643) in Insulin receptor substrate 1 (IRS1)
(6) Interaction #1 YWHAE - YWHAE

Interaction Regulation
PTM-dependent Induction (Phosphorylation of S641 on Insulin receptor substrate 1 (IRS1)) of the Insulin receptor substrate 1 (IRS1) LIG_14-3-3_3 motif - 14-3-3 protein interaction

Context
References

(1) 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
Ogihara et al. J. Biol. Chem. (1997)

See also

Other switches involving participants
Insulin receptor substrate 1 (IRS1) - 2 more (view)
14-3-3 protein epsilon (YWHAE) - 2 more (view)

Other switches involving interfaces
14-3-3 protein - 38 more (view)
LIG_14-3-3_3 - 16 more (view)




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