Description: Participants: Interactions ![]() 1Interaction #1 YWHAE - YWHAE Interfaces (1) 14-3-3 protein in 14-3-3 protein epsilon (YWHAE) (2) 14-3-3 protein (4-239) in 14-3-3 protein epsilon (YWHAE) 2Interaction #2 IRS1 - Interaction #1 YWHAE - YWHAE Requires Interaction #1 YWHAE - YWHAE Interfaces (3) LIG_14-3-3_3 motif (371HSRSIP376) in Insulin receptor substrate 1 (IRS1) (4) Interaction #1 YWHAE - YWHAE Interaction Regulation PTM-dependent Induction (Phosphorylation of S374 on Insulin receptor substrate 1 (IRS1)) of the Insulin receptor substrate 1 (IRS1) LIG_14-3-3_3 motif - 14-3-3 protein interaction 2Interaction #3 IRS1 - Interaction #1 YWHAE - YWHAE Requires Interaction #1 YWHAE - YWHAE Interfaces (5) LIG_14-3-3_3 motif (638KSVSAP643) in Insulin receptor substrate 1 (IRS1) (6) Interaction #1 YWHAE - YWHAE Interaction Regulation PTM-dependent Induction (Phosphorylation of S641 on Insulin receptor substrate 1 (IRS1)) of the Insulin receptor substrate 1 (IRS1) LIG_14-3-3_3 motif - 14-3-3 protein interaction Context References (1) 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. See also Other switches involving participants |
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