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Switch #:
SWTI000361
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y376 in the SH2-binding motif of 3-phosphoinositide-dependent protein kinase 1 (PDPK1) induces binding to the Tensin-1 (TNS1) protein.

Participants:
(1) 3-phosphoinositide-dependent protein kinase 1 (PDPK1)
(2) Tensin-1 (TNS1)

Interactions
Interaction #1 PDPK1 - TNS1

Interfaces
(1) ELM:LIG_SH2_IC motif (376YDNL379) in 3-phosphoinositide-dependent protein kinase 1 (PDPK1)
(2) SH2 domain (1463-1557) in Tensin-1 (TNS1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y376 on 3-phosphoinositide-dependent protein kinase 1 (PDPK1)) of the 3-phosphoinositide-dependent protein kinase 1 (PDPK1) LIG_SH2_IC motif - Tensin-1 (TNS1) SH2 domain interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y376 : Insulin-like growth factor 1 receptor (IGF1R), Proto-oncogene tyrosine-protein kinase Src (SRC).

Additional Information
Affinity : 0.27 µM
Context
Switch localisation
Inferred: focal adhesion
References

(1) A chemical approach to the identification of tensin-binding proteins.
Wavreille et al. ACS Chem. Biol. (2007)

See also

Other switches involving participants
Tensin-1 (TNS1) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IC - 12 more (view)


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