Switch #: SWTI000366

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y235 in the SH2-binding motif of Linker for activation of T-cells family member 1 (Lat) induces binding to the Growth factor receptor-bound protein 2 (Grb2) protein.

Participants:
(1) Linker for activation of T-cells family member 1 (Lat)
(2) Growth factor receptor-bound protein 2 (Grb2)

(1) Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
Zhang et al. J. Biol. Chem. (2000)

Other switches involving participants
Linker for activation of T-cells family member 1 (Lat) - 2 more (view)
Growth factor receptor-bound protein 2 (Grb2) - 2 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
LIG_SH2_GRB2 - 6 more (view)