Switches.ELM

Switch #:

SWTI000367

Switch type:
Binary

Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y402 in the SH2-binding motif of Docking protein 2 (DOK2) induces binding to the Tensin-1 (TNS1) protein.

Participants:
(1) Docking protein 2 (DOK2)
(2) Tensin-1 (TNS1)

Interactions

Interaction #1 DOK2 - TNS1

Interfaces
(1) ELM:LIG_SH2_IC motif (₄₀₂YDNV₄₀₅) in Docking protein 2 (DOK2)
(2) SH2 domain_(1463-1557) in Tensin-1 (TNS1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y₄₀₂ on Docking protein 2 (DOK2)) of the Docking protein 2 (DOK2) LIG_SH2_IC motif - Tensin-1 (TNS1) SH2 domain interaction

Additional Information
Affinity : 0.44 µM

References

(1) A chemical approach to the identification of tensin-binding proteins.
Wavreille et al. ACS Chem. Biol. (2007)