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Switch #:
SWTI000368
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y813 in the SH2-binding motif of Tyrosine-protein kinase JAK2 (JAK2) induces binding to the SH2B adapter protein 1 (SH2B1) protein.

Participants:
(1) Tyrosine-protein kinase JAK2 (JAK2)
(2) SH2B adapter protein 1 (SH2B1)

Interactions
Interaction #1 JAK2 - SH2B1

Interfaces
(1) ELM:LIG_SH2_IIB motif (804DLNSLFTPDYELLTENDMLP823) in Tyrosine-protein kinase JAK2 (JAK2)
(2) SH2 domain (527-604) in SH2B adapter protein 1 (SH2B1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y813 on Tyrosine-protein kinase JAK2 (JAK2)) of the Tyrosine-protein kinase JAK2 (JAK2) LIG_SH2_IIB motif - SH2B adapter protein 1 (SH2B1) SH2 domain interaction

Context
Switch localisation
Inferred: cytosol, nucleus
References

(1) Kinase activation through dimerization by human SH2-B.
Nishi et al. Mol. Cell. Biol. (2005)

See also

Other switches involving participants
Tyrosine-protein kinase JAK2 (JAK2) - 4 more (view)
SH2B adapter protein 1 (SH2B1) - 1 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IIB - 12 more (view)


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