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Switch #:
SWTI000369
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y220 in the SH2-binding motif of Disabled homolog 1 (DAB1) induces binding to the Adapter molecule crk (CRK) protein.

Participants:
(1) Disabled homolog 1 (DAB1)
(2) Adapter molecule crk (CRK)

Interactions
Interaction #1 DAB1 - CRK

Interfaces
(1) ELM:LIG_SH2_IB motif (211RDPETEENIYQVPTSQKKEG230) in Disabled homolog 1 (DAB1)
(2) SH2 domain (13-104) in Adapter molecule crk (CRK)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y220 on Disabled homolog 1 (DAB1)) of the Disabled homolog 1 (DAB1) LIG_SH2_IB motif - Adapter molecule crk (CRK) SH2 domain interaction

References

(1) Interaction between Dab1 and CrkII is promoted by Reelin signaling.
Chen et al. J. Cell. Sci. (2004)

See also

Other switches involving participants
Adapter molecule crk (CRK) - 7 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IB - 13 more (view)


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