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Switch #:
SWTI000370
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Growth factor receptor-bound protein 2 (GRB2)

Interactions
Context
References

(1) Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
Lemmon et al. J. Biol. Chem. (1994)

See also

Other switches involving participants
Epidermal growth factor receptor (EGFR) - 14 more (view)
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IC - 12 more (view)




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