Switch #: SWTI000370

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1092 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Growth factor receptor-bound protein 2 (GRB2) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Growth factor receptor-bound protein 2 (GRB2)

(1) Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.
Lemmon et al. J. Biol. Chem. (1994)

Other switches involving participants
Epidermal growth factor receptor (EGFR) - 14 more (view)
Growth factor receptor-bound protein 2 (GRB2) - 12 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_IC - 12 more (view)