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Switch #:
SWTI000371
Switch type:
Binary
Switch subtype:
Physicochemical compatibility

Description:
Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Ras and Rab interactor 1 (RIN1) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Ras and Rab interactor 1 (RIN1)

Interactions
Interaction #1 EGFR - RIN1

Interfaces
(1) ELM:LIG_SH2_IE motif (1011VDADEYLIPQ1020) in Epidermal growth factor receptor (EGFR)
(2) Ras and Rab interactor 1 (RIN1)

Interaction Regulation
PTM-dependent Induction (Phosphorylation of Y1016 on Epidermal growth factor receptor (EGFR)) of the Epidermal growth factor receptor (EGFR) LIG_SH2_IE motif - Ras and Rab interactor 1 (RIN1) interaction

Inferred Regulatory Enzymes for switch
Putative modifying enzymes for residue: Y1016 : Tyrosine-protein kinase ABL1 (ABL1), Epidermal growth factor receptor (EGFR), Proto-oncogene tyrosine-protein kinase Src (SRC).

Context
Switch localisation
Curated: cytoplasmic side of plasma membrane
References

(1) The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.
Barbieri et al. J. Biol. Chem. (2003)

See also

Other switches involving participants
Epidermal growth factor receptor (EGFR) - 14 more (view)
Ras and Rab interactor 1 (RIN1) - 1 more (view)

Other switches involving interfaces
ELM:LIG_SH2_IE - 11 more (view)
IPR:IPR000980 - 9 more (view)


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