Switch #: SWTI000372

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1197 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Ras and Rab interactor 1 (RIN1) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Ras and Rab interactor 1 (RIN1)

(1) The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis.
Barbieri et al. J. Biol. Chem. (2003)

Other switches involving participants
Epidermal growth factor receptor (EGFR) - 14 more (view)
Ras and Rab interactor 1 (RIN1) - 1 more (view)

Other switches involving interfaces
ELM:LIG_SH2_IE - 11 more (view)
IPR:IPR000980 - 9 more (view)