Switch #: SWTI000377

Switch type: Binary

Switch subtype: Physicochemical compatibility

Description:
Phosphorylation of Y1016 in the SH2-binding motif of Epidermal growth factor receptor (EGFR) induces binding to the Signal transducer and activator of transcription 6 (STAT6) protein.

Participants:
(1) Epidermal growth factor receptor (EGFR)
(2) Signal transducer and activator of transcription 6 (STAT6)

(1) A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Jones et al. Nature (2006)

Other switches involving participants
Epidermal growth factor receptor (EGFR) - 14 more (view)
Signal transducer and activator of transcription 6 (STAT6) - 5 more (view)

Other switches involving interfaces
SH2 domain - 140 more (view)
ELM:LIG_SH2_III - 15 more (view)